GM1 ganglioside regulates the proteolysis of amyloid precursor protein
نویسندگان
چکیده
منابع مشابه
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
Cellular cholesterol levels alter the processing of the amyloid precursor protein (APP) to produce Abeta. Activation of liver X receptors (LXRs), one cellular mechanism to regulate cholesterol homeostasis, has been found to alter Abeta levels in vitro and in vivo. To identify genes regulated by LXR, we treated human neuroblastoma cells with an LXR agonist (TO-901317) and examined gene expressio...
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Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of Aβ production, are enriched in amyloid plaques and bind amyloid beta (Aβ). However, the molecular mechanisms linking gangliosides with AD are unknown. Here we identified the previously unknown function of the amyloid precursor protein (APP...
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β-Amyloid (Aβ) oligomers are neurotoxic and implicated in Alzheimer's disease. Neuronal plasma membranes may mediate formation of Aβ oligomers in vivo. Membrane components sphingomyelin and GM1 have been shown to promote aggregation of Aβ; however, these studies were performed under extreme, non-physiological conditions. We demonstrate that physiological levels of GM1 , organized in nanodomains...
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D i s s e r t a t i o n zur Erlangung des akademischen Grades des Doktors der Naturwissenschaften d o c t o r r e r u m n a t u r a l i u m Summary Alzheimer disease (AD) is the most common form of neurodegenerative diseases. Only little is known about the control mechanisms which affect APP metabolism and that cause Alzheimer´s Disease. Gene expression profiling studies revealed reduced levels...
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Introduction: Iron oxide nanoparticles (Fe2O3-NPs) are small magnetic particles that widely used in different aspects of biology and medicine in modern life. Fe2O3-NP accumulated in the living cells due to absence of active system to excrete the iron ions so damages cellular organelles by highly reactivity. Method: Herein cytotoxic effects of Fe2O3-NP with 50 nm size were investigated on prima...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2004
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001509